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Despite the relatively short half-life, clinical effects can persist for several hours to days after administration, suggesting that pharmacodynamic effects outlast plasma drug levels through persistent changes in neural circuit activity initiated by melanocortin receptor activation

10.1038/s41467-017-01651-9 59 MaF.ZhangL.WestlundK

Kalicki RM, Uehlinger DE

Youre supporting a molecule it already relies on, one whose production tends to decline with age, chronic stress, poor nutrition, and certain health conditions

[DOI] [PubMed] [Google Scholar] 21.Lutz T

If there are no recurrent seizures, the patient will hopefully awaken and may be extubated